The Sinister Six was created by Doctor Octopus to defeat Spider-Man by combining the powers of several of his greatest foes. Over the years, the lineup has changed, but the team's goal remains the same: to eliminate Spider-Man. They have appeared in various story arcs and adaptations, solidifying their status as one of Spider-Man's most formidable adversaries.
A team of supervillains in the Marvel Universe, primarily formed to take down Spider-Man.